The Longevity Compound Your Body Makes Less of Every Decade

This compound slows biological aging. Here's how to get it back.

Your cells run a continuous cycle of chemical reactions to make energy. Alpha-ketoglutarate (AKG) is one of the key players in the citric acid cycle (the sequence of reactions your mitochondria use to convert food into usable energy). In your 20s, your body produces and circulates AKG in abundance. By later adulthood, circulating levels are much lower.

Lower AKG levels affect more than energy production. AKG is a required cofactor (a helper molecule an enzyme needs to function) for TET enzymes, proteins responsible for clearing methylation marks (chemical tags placed on DNA over time that influence which genes your body reads) from the genome. When AKG levels drop, those tags accumulate in patterns associated with biological aging. Studies also show AKG reduces mTOR signaling. mTOR is a nutrient-sensing pathway (a system your cells use to detect food availability and adjust growth and repair accordingly) contributing to accelerated aging when it’s chronically overactivated.

In the full version you’ll get:

-The research behind AKG supplementation

-The specific form scientists used in studies and why form selection changes outcomes

-Exact dosing, timing, and what to track

-How to stack AKG with other longevity interventions

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