Dave Asprey's Substack

Dave Asprey's Substack

The $30 Supplement That Touches Nearly Every Longevity Pathway at Once

One of the most underrated additions to a serious longevity stack.

Jun 15, 2026
∙ Paid

I’ve had EGCG in my stack for years. Most people know it as the active compound in green tea. What most people don’t know is that green tea itself is actually not a great way to get it.

Commercial green tea is high in oxalates, which bind to minerals and contribute to kidney stones and systemic issues. It’s also a significant source of fluoride, which accumulates in the pineal gland and disrupts sleep and hormonal signaling. A standardized extract gives you what you want without the baggage.

EGCG is one of the few compounds with research spanning mitochondrial function, cellular stress responses, inflammation, glycation, and brain health. A new study on its protective effects against severe cellular stress gave me another reason to keep it in my daily stack.

In the full version you’ll get:

  • The longevity pathways EGCG influences and the science behind them

  • What to stack it with and the synergies the research supports

  • How to find a quality product

  • The full dosing and timing protocol

[Subscribe to unlock the full protocol]

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