Complete Your Sirtuin Stack: What to Take Alongside Resveratrol
What actually works and how to activate your longevity genes with these science-backed compounds that deliver superior results.
I dive into tomorrow's biohacking breakthroughs so you don't waste time on yesterday's trends. I'll show you how to implement cutting-edge longevity protocols and performance compounds before they go mainstream… so you optimize faster, perform better, and age slower than everyone else.
In the world of longevity, we’ve been using resveratrol for 30 years. Now scientists understand that it’s because of what it does to Sirtuins.
Sirtuins are seven proteins (SIRT1-SIRT7) that regulate how your cells age, repair damage, and produce energy. They function as NAD⁺-dependent enzymes—your cellular maintenance crew that repairs DNA, reduces inflammation, optimizes mitochondrial function, and helps cells resist stress. Activating them effectively represents one of the most promising strategies for extending lifespan and improving metabolic health.
Big problem: less than one percent of the resveratrol you take actually gets in. Early research suggested resveratrol directly activated SIRT1, but those studies used fluorophore-tagged substrates that created measurement artifacts. A 2025 meta-analysis confirms resveratrol supplementation doesn’t significantly shift human SIRT1 expression or serum levels on its own.
But there’s something you can do.
You can add complementary compounds that amplify sirtuin activation beyond what resveratrol delivers alone. I’ve tested bioavailable options with clearer mechanisms that work synergistically with resveratrol—compounds that hit therapeutic sirtuin activation levels you can’t achieve with resveratrol by itself.
Think of resveratrol as your foundation. Now build on it with targeted activators that reach the sirtuins resveratrol misses and enhance the pathways it touches.
Maximizing sirtuin activation requires a multi-angle approach most longevity protocols overlook.
In the paid section, I show you how to stack strategically:
Why I combine NAD⁺ precursors with specific sirtuin activators for synergistic effects
How I solve the CD38 problem to prevent “leaky NAD⁺ bucket” and amplify results
Which compounds I add to resveratrol for complete sirtuin coverage
Why I prioritize certain sirtuins for longevity (and why SIRT6 stands out)
My real-world dosing protocols, stacking combinations, cycling strategies, and safety guidelines
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