Exercise does something awesome to your cells. Ask your body to produce more energy over and over again, and it starts changing the machinery that makes energy. Your muscles adapt to use oxygen better, your mitochondria respond to the higher demand, and your metabolism becomes more capable of using fat as fuel.
Now imagine getting some of those changes from a pill.
SLU-PP-332 is an experimental compound that has generated a striking set of exercise-like effects in mice.
SLU-PP-332 activates three proteins called estrogen-related receptors, or ERRs. The name sounds like these receptors have something to do with estrogen, but they don’t. ERRs help regulate energy metabolism throughout your body, especially in tissues that consume large amounts of energy. That includes your skeletal muscle, heart, brain, and kidneys.
Exercise naturally activates this system. When your muscles need more energy, ERRs help coordinate the cellular response. SLU-PP-332 takes a shortcut to that response.
In mice, it increased oxidative muscle fibers, mitochondrial activity, fat oxidation, and energy expenditure. The animals also performed better on endurance tests. In obese mice, the compound reduced fat accumulation and improved insulin sensitivity.
The problem is that SLU-PP-332 doesn’t make a great oral drug.
The original studies relied on intraperitoneal injections. One metabolic-syndrome study gave mice 50 mg/kg twice a day for up to 28 days. You can’t turn that number into a human capsule with a simple weight conversion. The route of administration changes absorption and exposure, and nobody has established human pharmacokinetics for SLU-PP-332.
But that doesn’t make SLU-PP-332 irrelevant.
Here’s what we’ll get into in the full version:
How SLU-PP-332 makes you lose fat and improves endurance.
Using + dosing SLU-PP-332, where to source it.
The newest compound related to SLU-PP-332 that might be even better.
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